This research demonstrates the effects of testosterone on muscle growth in a model of sarcopenia, highlighting the role of satellite cells and inflammation.
Key Points
Testosterone treatment improved muscle fibre thickness and activated satellite cells in sarcopenic models, suggesting potential therapies.
The muscle organoid model exhibited significant structural maturity and functional interaction with spinal-derived neurons.
Chronic TNF-α was used to induce sarcopenia-like conditions, facilitating the study of muscle regeneration mechanisms.
These findings support the use of human pluripotent stem cell-derived organoids for understanding aging-related muscle loss.