October 1, 2025MedicineOpen Access

Precision management of community-acquired pneumonia in children: An applied study combining traditional detection of alveolar lavage fluid pathogenesis with multiplexed targeted nanopore sequencing

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Discussion

Applied study evaluates pathogen detection methods and serological markers in children with pneumonia, suggesting improved diagnosis accuracy.

Improved pathogen detection using targeted nanopore sequencing, with a rate of 37.74% vs. 18.87% for culture.
Majority of infections were mycoplasma (72.38%) in children over 6 years; bacterial infections predominated in younger children.
Serological markers exhibited significant differences based on infection type, influencing clinical diagnosis and treatment.
Integration of traditional methods with nanopore sequencing enhances diagnostic accuracy, indicating a trend towards precision medicine.

Guo et al. (2025) studied this question.

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Applied study evaluates pathogen detection methods and serological markers in children with pneumonia, suggesting improved diagnosis accuracy.