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August 26, 2025MedScienOpen Access

Research on Tumor Drug Resistance Mediated by Epithelial-mesenchymal Transition

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Authors

YWYou Wu

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Overview

This review explores how epithelial-mesenchymal transition drives drug resistance in cancer cells, suggesting new treatment strategies that may improve outcomes.

Key Points

  • Epithelial-mesenchymal transition (EMT) significantly contributes to tumor drug resistance, affecting treatment efficacy and patient outcomes.
  • Current research links EMT with mechanisms like stem cell-like properties, drug efflux, and miRNA delivery via exosomes, highlighting pathways involved.
  • A systematic review assesses strategies targeting EMT to reverse drug resistance, emphasizing the need for effective clinical applications.
  • Future studies should focus on selective targeting of EMT, refining biomarkers, and improving synergy with existing therapies to enhance prognosis.

Cite This Study

You Wu (2025) studied this question.

synapsesocial.com/papers/68af7df27567bf4f94ff4f6ahttps://doi.org/10.61173/g7ea4081
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epithelial–Mesenchymal Transition in Cancer: Insights Into Therapeutic Targets and Clinical Implications2025
  2. 2Epithelial-mesenchymal dynamics in cancer: Role of signalling pathways, stromal interactions and natural therapies2025 · 3 citations
  3. 3How metastatic cancer cells escape immune system detection through EMT2024
  4. 4The Tumor Microenvironment: Impact on Tumor Growth, Metastasis, and Therapeutic Resistance: A Systematic Review2025
  5. 5The Underlying Mechanisms and Emerging Strategies to Overcome Resistance in Breast Cancer2025 · 20 citations