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September 10, 2025NutrientsOpen Access

The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Translation—A Narrative Review

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Authors

ACAndrea CeglédiMFMónika FeketeTJTamás Jarecsny

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Overview

This narrative review explores curcumin’s effects on neurodegenerative disorders, highlighting its neuroprotective mechanisms and clinical implications.

Key Points

  • Curcumin exhibits significant neuroprotective effects against neurodegenerative disorders like Alzheimer’s and Parkinson’s.
  • Preclinical studies demonstrate curcumin’s efficacy, showing improved outcomes in rodent models of Alzheimer’s disease and stroke.
  • Curcumin’s antioxidant and anti-inflammatory properties are crucial in mitigating oxidative stress and neuroinflammation.
  • Challenges in curcumin’s clinical application include its poor oral bioavailability and the need for advanced delivery systems.

Cite This Study

Ceglédi et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478c63dhttps://doi.org/10.3390/nu17172884
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigating The Neuroprotective Role of Curcumin in Alzheimer's Disease Models2025 · 2 citations
  2. 2Neuroprotective Potential of Curcumin in Neurodegenerative Diseases: Clinical Insights Into Cellular and Molecular Signaling Pathways.2025
  3. 3Curcumin and neuroplasticity: epigenetic mechanisms underlying cognitive enhancement in aging and neurodegenerative disorders2025
  4. 4Anti-inflammatory effect of curcumin on neurological disorders: a narrative review2025
  5. 5Curcumin and Dementia: A Systematic Review of Its Effects on Oxidative Stress and Cognitive Outcomes in Animal Models2025