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September 10, 2025Pediatric Critical Care Medicine

Urine Output Trajectories and Dialysis Independence in Critically Ill Children With Acute Kidney Injury: A Single-Center Retrospective Cohort Study, 2014–2023

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Authors

YTYusuke TokudaKIKentaro IdeJMJunichiro Morota

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Overview

Retrospective cohort study shows urine output predicts dialysis independence in critically ill children, suggesting improved outcomes.

Key Points

  • Higher urine output at day 14 predicts dialysis independence by day 30 after continuous kidney replacement therapy.
  • Patients with dialysis dependence showed significantly lower urine output compared to those who were dialysis independent across several time points.
  • The area under the ROC curve for predicting dialysis independence based on urine output at day 14 was 0.96, indicating excellent predictive ability.
  • In a cohort of critically ill children with AKI, a urine output threshold of 0.41 mL/kg/hr at day 14 may serve as a reliable test for future dialysis independence.

Cite This Study

Tokuda et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478c31chttps://doi.org/10.1097/pcc.0000000000003826
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predicting mortality and short-term outcomes of continuous kidney replacement therapies in neonates and infants2025
  2. 2Predictive Factors for Successful Discontinuation of Continuous Renal Replacement Therapy: A Retrospective Single-Center Observational Study.2026
  3. 3Factors associated with successful transition from continuous renal replacement therapy in critically ill patients: a retrospective cohort study2025
  4. 4Impact of Early Initiation of Renal Replacement Therapy on Renal Recovery and Mortality in Critically Ill Patients with Acute Kidney Injury: A Prospective Cohort Study2025 · 3 citations
  5. 5Growth in neonates with congenital kidney failure requiring continuous kidney replacement therapy2025