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October 23, 2025BiomedicinesOpen Access

Impact of Early Initiation of Renal Replacement Therapy on Renal Recovery and Mortality in Critically Ill Patients with Acute Kidney Injury: A Prospective Cohort Study

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Authors

RMRayane Alves MoreiraSBSheila de Melo BorgesSBS Borges

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Overview

Prospective cohort study shows early renal replacement therapy may enhance renal recovery in critically ill patients, indicating timing impacts outcomes.

Key Points

  • Early renal replacement therapy improved recovery within 3 days but did not affect mortality rates.
  • Mortality analysis revealed no significant differences across groups at 20, 30, and 76 days post-treatment.
  • Observed clinical severity was higher in the early intervention group, emphasizing urgency in treatment choice.
  • Findings suggest that while early therapy boosts renal recovery, it does not lower the risk of mortality in acute kidney injury.

Cite This Study

Moreira et al. (2025) studied this question.

synapsesocial.com/papers/68fa1210f9f8b44535bfceachttps://doi.org/10.3390/biomedicines13112575
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early versus Delayed Initiation of Renal Replacement Therapy in Critically Ill Patients with Acute Kidney Injury: A Systematic Review and Meta-Analysis of Randomized Trials2025
  2. 2The early bird in renal rescue: timing matters in acute kidney injury management—insights from target trial emulation2025
  3. 3Timing of renal-replacement therapy in patients with acute kidney injury and sepsis: a systematic review and meta-analysis2026
  4. 4Evaluation of Outcomes After Early Versus Late Initiation of Continuous Renal Replacement Therapy in Adult Patients With Sepsis-Associated Acute Kidney Injury2026
  5. 5Clinical Markers Predicting Mortality in Patients Receiving Renal Replacement Therapy in the Intensive Care Unit: A One-Year Retrospective Study2025