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August 7, 2025Renal FailureOpen Access

Factors associated with successful transition from continuous renal replacement therapy in critically ill patients: a retrospective cohort study

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Authors

RMRonald MillerAAAbdel-Rauof AkkariAMAhmad Matarneh

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Overview

Retrospective cohort study identifies urine output and vasopressor use as key predictors for CRRT discontinuation in critically ill patients, suggesting targeted management strategies.

Key Points

  • MAIN FINDING: Most patients (89%) successfully transitioned off continuous renal replacement therapy following acute kidney injury.
  • KEY EVIDENCE: Higher urine output and better acid-base status were positively associated with successful therapy discontinuation.
  • APPROACH: A retrospective analysis of 924 ICU patients used multivariable logistic regression to assess clinical factors impacting CRRT transition.
  • SIGNIFICANCE: Identifying predictors aids in improving management and outcomes for critically ill patients requiring renal support.

Cite This Study

Miller et al. (2025) studied this question.

synapsesocial.com/papers/689dfe9fd61984b91e13c429https://doi.org/10.1080/0886022x.2025.2539933
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predictive Factors for Successful Discontinuation of Continuous Renal Replacement Therapy: A Retrospective Single-Center Observational Study.2026
  2. 2Clinical Markers Predicting Mortality in Patients Receiving Renal Replacement Therapy in the Intensive Care Unit: A One-Year Retrospective Study2025
  3. 3Clinical impact and safety of continuous renal replacement therapy in critically ill patients with solid tumors and acute kidney injury: a retrospective cohort analysis2025
  4. 4Proceedings of the UAB CRRT Academy (2023-2024): Managing De-Escalation of Acute RRT and Optimizing Drug Dosing During RRT Transitions.2025
  5. 5Prognosis of critically ill patients with cirrhosis and acute kidney injury initiated on dialysis2026