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January 8, 2026Journal of Clinical MedicineOpen Access

Asymptomatic Aortic Regurgitation: Evolving Imaging Markers and Contemporary Intervention Strategies

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Key result

Impaired left ventricular global longitudinal strain (GLS <−15%) predicts a fourfold increase in mortality risk in asymptomatic patients with severe aortic regurgitation.

Authors

CTChieh-Mei TsaiKLKuan-Yu LaiYSYu‐Jang Su

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Overview

This narrative review uncovers evolving imaging and intervention strategies for asymptomatic aortic regurgitation, indicating a need for earlier intervention.

Key Points

  • The aim is to explore advances in imaging and intervention strategies for asymptomatic aortic regurgitation.
  • Narrative synthesis of contemporary literature
  • Review of recent clinical studies
  • Assessment of imaging advancements
  • Evaluation of guideline documents
  • Early detection of myocardial remodeling can precede symptoms or dysfunction.
  • Multimodal imaging offers improved risk stratification compared to conventional metrics.
  • Evolving interventions include valve repairs and transcatheter replacements in high-risk patients.

PICO

P
Population
asymptomatic aortic regurgitation
I
Intervention / Comparator
aortic valve replacement, valve-sparing root replacement, Ross procedure, transcatheter aortic valve replacement
O
Primary Outcome
all-cause mortality, cardiovascular mortality, or need for aortic valve surgery — HR 4.0 (2.5-6.4), p=<0.001

Main Result

Effect estimate: HR 4.0 (95% CI 2.5-6.4)

p-value: p=<0.001

Limitations

  • Lack of randomized trials directly comparing aortic valve interventions
  • Limited long-term durability data for newer transcatheter devices
  • Reliance on observational data with potential referral and selection biases.

Cite This Study

Tsai et al. (2026) studied asymptomatic aortic regurgitation. aortic valve replacement, valve-sparing root replacement, Ross procedure, transcatheter aortic valve replacement was evaluated on all-cause mortality, cardiovascular mortality, or need for aortic valve surgery (HR 4.0, 95% CI 2.5-6.4, p=<0.001). Impaired left ventricular global longitudinal strain (GLS <−15%) predicts a fourfold increase in mortality risk in asymptomatic patients with severe aortic regurgitation.

synapsesocial.com/papers/69608779fa51ca23bb98098fhttps://doi.org/10.3390/jcm15010339
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