Comorbidity-Associated Adverse Drug Reactions During Tuberculosis Treatment: A Prospective Study

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Discussion

Observational study shows higher adverse drug reactions in TB patients with comorbidities, suggesting tailored pharmacovigilance is needed.

The prevalence of adverse drug reactions was 49.33%, significantly higher in patients with comorbidities.
Comorbid patients had a 55.91% rate of adverse drug reactions compared to 46.37% in those without comorbidities.
Patients with diabetes mellitus experienced the highest rate of adverse drug reactions at 60.53%, indicating higher vulnerability.
Gastrointestinal adverse drug reactions were the most common, suggesting a need for increased monitoring and tailored therapies.

Karthick et al. (2025) studied this question.

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Observational study shows higher adverse drug reactions in TB patients with comorbidities, suggesting tailored pharmacovigilance is needed.