Retrospective assessment of adverse drug reactions linked to first-line antituberculosis drugs at a tertiary healthcare facility in Northern India

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Discussion

Retrospective analysis of adverse drug reactions in patients on first-line anti-tubercular therapy reveals concerning trends during treatment phases.

Drug-induced hepatitis was observed in 58.8% of patients receiving first-line anti-tubercular therapy, highlighting a significant safety concern.
Data analysis included 102 reports of adverse drug reactions collected by the Pharmacovigilance Programme of India from 2015 to 2018.
Retrospective assessment using the modified Hartwig and Siegel scale helped determine the severity of reported adverse drug reactions.
Strengthening monitoring for adverse drug reactions is crucial for improving treatment adherence and overall patient safety.

Kumar et al. (2025) studied this question.

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Retrospective analysis of adverse drug reactions in patients on first-line anti-tubercular therapy reveals concerning trends during treatment phases.