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August 1, 2025Indus journal of bioscience research.Open Access

Renoprotective Effects of RAAS Inhibitors in Patients with Diabetic Nephropathy: A Comprehensive Meta-Analysis of Randomized Controlled Trials

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Authors

MSMohammed ShihasMSM. Naveed ShaikFKFarrukh Aslam Khan

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Overview

Meta-analysis evaluates RAAS inhibitors' impact on kidney function in diabetic nephropathy, indicating potential for combination therapies.

Key Points

  • RAAS inhibitors significantly slowed annual decline in eGFR and reduced albuminuria by 18–30%, improving kidney health.
  • The meta-analysis incorporated data from 7 RCTs involving 10,500 participants, focusing on renal function and proteinuria outcomes.
  • Analysis utilized a random-effects model with study quality assessed via the Cochrane RoB 2.0 tool, ensuring robust results.
  • Combination therapies showed enhanced efficacy but a modestly increased risk of hyperkalemia, emphasizing careful monitoring.

Cite This Study

Shihas et al. (2025) studied this question.

synapsesocial.com/papers/68af2d76cf1dd9ea359e53aahttps://doi.org/10.70749/ijbr.v3i8.1976
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RAAS Inhibitors for the Primary Prevention of CKD in Type 1 and Type 2 Diabetes: A Systematic Review and Meta-analysis2026
  2. 2Non-steroidal mineralocorticoid receptor antagonists in non-diabetic kidney disease: a narrative review of mechanisms and clinical advances2026
  3. 3Evaluating the Efficacy of Finerenone in Reducing Proteinuria in Diabetic Nephropathy Patients Receiving Maximum Tolerable Doses of Dapagliflozin and Telmisartan2025
  4. 4Nonsteroidal mineralocorticoid receptor antagonist in diabetic kidney disease: mechanistic insights and clinical integration2026
  5. 5Finerenone in Chronic Kidney Disease: A Comprehensive Review of Mechanisms, Efficacy and Safety2025 · 8 citations