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September 10, 2025HypertensionOpen Access

Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin Receptor Blockers: Multidatabase Target Trial Emulation Studies

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Authors

CXChao XieRCRuixuan ChenSZShi-Yu Zhou

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Overview

Multidatabase cohort study shows ACE inhibitors may increase all-cause mortality compared to ARBs, highlighting treatment choices.

Key Points

  • Patients initiating ACE inhibitors had a 5-year all-cause mortality of 3.45%, higher than the 3.04% for ARBs.
  • In the UK Biobank, hazard ratios indicated a 1.13-fold risk increase for ACE inhibitors over ARBs.
  • Propensity score matching balanced baseline characteristics in a multidatabase target trial emulation study.
  • Findings suggest careful consideration of angiotensin-aldosterone system inhibitors for heart and kidney health.

Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64786e59https://doi.org/10.1161/hypertensionaha.125.25549
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