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September 10, 2025Frontiers in EndocrinologyOpen Access

Regulation of osteogenic differentiation in vascular smooth muscle cells under high-glucose condition

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Authors

JGJingjing GuoLDLaijing Du

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Overview

This review explores how high glucose enhances vascular calcification in vascular smooth muscle cells, indicating critical metabolic pathways involved.

Key Points

  • High glucose levels trigger osteogenic differentiation in vascular smooth muscle cells, leading to vascular calcification.
  • Hyperglycemia activates pathways such as PKC and dysregulates metabolic processes, contributing to VC.
  • Advanced glycation end products play a significant role in the metabolic reprogramming of vascular smooth muscle cells.
  • The review outlines multiple mechanisms behind hyperglycemia-induced vascular calcification and its implications.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/68c23c66b210217d64789072https://doi.org/10.3389/fendo.2025.1589160
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glucose and Smooth Muscle Cells: Unraveling the Metabolic Signals Behind Vascular Calcification2025
  2. 2Role and mechanisms of vascular smooth muscle cell phenotypic transition in diabetic macrovascular complications2026
  3. 3Cellular and Molecular Mechanisms of VSMC Phenotypic Switching in Type 2 Diabetes2025
  4. 4Glycolysis and hexosamine biosynthesis regulate inflammatory protein expression and maturation and key steps of monocyte recruitment by human aortic valve cells2026
  5. 5Vascular smooth muscle cell metabolic reprogramming and phenotypic remodeling in atherosclerosis2025