September 5, 2025CellsOpen Access

Cellular and Molecular Mechanisms of VSMC Phenotypic Switching in Type 2 Diabetes

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VSMC phenotypic switching is crucial in the progression of complications associated with type 2 diabetes, influencing vascular health.
Key factors include obesity and insulin resistance, which drive VSMC transformation to inflammatory and proliferative states.
The review integrates findings over 15 years on the signaling pathways and regulators affecting VSMC behavior in disease contexts.
Understanding these mechanisms may open avenues for targeted therapies in type 2 diabetes-related vascular conditions.

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Review highlights cellular mechanisms driving VSMC phenotypic switching in type 2 diabetes, suggesting potential targets.

Gupta et al. (2025) studied this question.

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