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September 10, 2025Science World JournalOpen Access

Antibacterial activity of aqueous and methanolic extracts of Polyalthia longifolia and Hyptis suaveolens against clinically relevant isolates from Nigerian Defence Academy Hospital, Kaduna, Nigeria

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Authors

BIBabatunde Abdul-rauf IsamotuKDKarderam Bukar DikwaJAJoseph Appah

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Overview

This study evaluates antibacterial activity of polyalthia longifolia and hyptis suaveolens, suggesting potential against multidrug-resistant pathogens.

Key Points

  • Both plant extracts showed significant antibacterial activity, with polyalthia longifolia achieving MICs as low as 1.0 mg/mL, rivaling ciprofloxacin.
  • Aqueous and methanolic extracts exhibited different yields dependent on solvents, indicating distinct phytochemical profiles.
  • GC-MS profiling identified key antimicrobial constituents, including lauric acid derivatives in polyalthia longifolia and γ-sitosterol in hyptis suaveolens.
  • These findings support the use of plant extracts as cost-effective adjuncts to conventional antibiotics in resource-limited settings.

Cite This Study

Isamotu et al. (2025) studied this question.

synapsesocial.com/papers/68c23c66b210217d64788b29https://doi.org/10.4314/swj.v20i2.48
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antimicrobial Activity of Volatile and Non-Volatile Extracts of <em>Hyptis suaveolens</em> Leaves2025
  2. 2Phytochemical Analysis and Biological Activity of the Leaf Extracts of Polyalthia longifolia (Masquerade Tree)2025
  3. 3Synergistic Antibacterial Effects of Leaf Extracts of Acacia nilotica and Psidium guajava against Extended Spectrum Beta Lactamase (ESBL) Producing E. coli and Klebsiella pneumoniae2024
  4. 4Isolation and Characterization of Methanolic Stem Bark Extracts of <i>Polyalthia longifolia</i> and Root Extract of <i>Annona senegalensis</i> Plants2025
  5. 5Phenotypic Antibacterial Resistance Profiles of Azadirachta indica and Calotropis procera Fresh Leaf Extracts Against Multidrug-Resistant Pathogens2025