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September 10, 2025International Journal of NanomedicineOpen Access

Stem Cell-Derived Exosomes: A Comprehensive Review of Biomedical Applications, Challenges, and Future Directions

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Authors

JZJingyi ZhangXTXiumei TianYLYi Li

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Overview

Comprehensive review identifies significant therapeutic potential of stem cell-derived exosomes, highlighting current challenges in clinical translation.

Key Points

  • SC-Exos show significant therapeutic potential with advantages like reduced ethical controversies and immunogenicity.
  • The review evaluates the clinical translation status, highlighting favorable safety profiles and promising preliminary efficacy.
  • Standardization of isolation techniques and scalable production capabilities pose significant challenges for SC-Exos.
  • Future research should focus on optimizing administration routes, dosing regimens, and conducting large-scale multicenter clinical trials.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c23c20b210217d647877ffhttps://doi.org/10.2147/ijn.s527137
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  5. 5Clinical Frontiers of Exosome Research: A Comprehensive Analysis of Human Trials in Diagnostics, Therapeutics, and Regenerative Medicine2025