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August 16, 2025HSS Journal® The Musculoskeletal Journal of Hospital for Special SurgeryOpen Access

Clinical Status of Exosomes: A Review

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Authors

JSJonathan SgaglioneENEric V. NeufeldPSPooja Swami

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Overview

This review outlines exosomes' roles in intercellular communication and clinical challenges, suggesting their use in managing degenerative disorders.

Key Points

  • Exosomes influence various cellular processes, including immune modulation and tissue repair, signaling their significance in therapy.
  • Potential applications in managing degenerative disorders like osteoarthritis and osteoporosis suggest promising therapeutic roles.
  • The article reviews clinical challenges and innovative engineering strategies to enhance the efficacy of exosome therapy.
  • Exosomes offer advantages over whole-cell therapies by minimizing risks like immunogenicity and infusion toxicity.

Cite This Study

Sgaglione et al. (2025) studied this question.

synapsesocial.com/papers/68af3e49cf1dd9ea359eb6d1https://doi.org/10.1177/15563316251362179
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