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September 10, 2025International Journal of Molecular SciencesOpen Access

Multifunctional Activity of Syzygium aromaticum Extracts Against Candida albicans: Free Radicals, Membrane Permeabilization and Cdr1p Localization

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Authors

DDDaria DerkaczLCLiliana CebulaAKAnna Krasowska

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Overview

Observational analysis shows eugenol disrupts membrane integrity in Candida albicans, indicating new antifungal potential.

Key Points

  • Eugenol from Syzygium aromaticum shows significant antifungal effects against Candida albicans, reducing its growth.
  • Increased reactive oxygen species were observed in Candida albicans when exposed to eugenol extracts.
  • Eugenol causes plasma membrane disruption and affects Cdr1p localization in Candida albicans strains deprived of ergosterol.
  • The findings suggest that eugenol acts through both ergosterol-dependent and -independent mechanisms.

Cite This Study

Derkacz et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64786e00https://doi.org/10.3390/ijms26178571
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Natural products eugenol and cinnamaldehyde as potential therapeutic alternatives against <i>Candida auris</i> infections2025
  2. 2Eugenol Exhibits Antimutagenic Activity in Model Yeast Schizosaccharomyces pombe by Regulating DNA Damage Repair System: A Transcriptomic Analysis2025
  3. 3Galactose Inhibits the Translation of Erg1 that Enhances the Antifungal Activities of Azoles Against Candida albicans2025
  4. 4Targeting Candida albicans Infections through Synergistic Phytochemical and Antifungal Combinations2026
  5. 5Efficacy of Medicinal Plants in the In Vitro Control of Candida Albicans2025