Review explores synergistic effects of phytochemicals and antifungals, enhancing effectiveness against Candida albicans infections.
Key Points
The review aims to evaluate how combining phytochemicals with antifungal agents can improve treatment against Candida albicans infections and reduce resistance.
Review of recent studies on phytochemical and antifungal combinations
Emphasis on synergistic mechanisms involving azoles, polyenes, and echinocandins
Analysis of effects on fungal cell membrane integrity and biofilm formation
Phytochemicals enhance the efficacy of antifungal agents, improving treatment outcomes
Combination strategies reduce dosage requirements for conventional antifungals, minimizing toxicity
Mechanisms include disruption of cell membrane integrity and induction of oxidative stress, thereby impairing fungal virulence