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August 1, 2025Journal of Applied Microbiology

Natural products eugenol and cinnamaldehyde as potential therapeutic alternatives against Candida auris infections

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Authors

DSDébora Silva Marques de SousaGMGabrielle Pires de Morais MonariCRCatarina Rosa

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Overview

Experimental evaluation reveals eugenol and cinnamaldehyde's antifungal effects on Candida auris, suggesting potential for new treatments.

Key Points

  • Eugenol and cinnamaldehyde demonstrated fungicidal action against candida auris at 31.25 to 250 µg/mL concentration.
  • Sensitivity tests showed that eugenol had no cytotoxic effects, while cinnamaldehyde was cytotoxic at similar concentrations.
  • Proteomic analysis indicates that the mechanism of action relates to ergosterol biosynthesis, essential for fungal cell membranes.
  • These findings highlight eugenol as a promising candidate for developing therapies to combat candida auris infections.

Cite This Study

Sousa et al. (2025) studied this question.

synapsesocial.com/papers/68af76bf7567bf4f94feffe5https://doi.org/10.1093/jambio/lxaf197
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