Impact of red blood cell exchange on echocardiographic parameters among adults with sickle cell disease

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Red blood cell exchange significantly decreased tricuspid regurgitant jet velocity in patients with sickle cell disease.
The average TRJV dropped from 2.59 m/s pre-RCE to 2.43 m/s post-RCE, indicating improved cardiac function.
Patients with elevated TRJV at baseline experienced a more significant reduction compared to those with non-elevated TRJV.
Effects of chronic red blood cell exchange on left ventricular function parameters appeared negligible after follow-up.

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Retrospective analysis shows reduced TRJV following red blood cell exchange in adults with sickle cell disease, indicating cardiovascular benefits.

Mercier‐Ross et al. (2025) studied this question.

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Retrospective analysis shows reduced TRJV following red blood cell exchange in adults with sickle cell disease, indicating cardiovascular benefits.