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September 10, 2025OncoTargets and TherapyOpen Access

The Dual Role of RBBP7 in Esophageal Squamous Cell Carcinoma: Cell Context-Dependent Impacts on Proliferation and Radiosensitivity

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Authors

YLYafen LiSLShuai LüHYHui Yao

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Overview

Analysis reveals RBBP7 affects proliferation and radiosensitivity in esophageal squamous cell carcinoma, suggesting therapeutic potential.

Key Points

  • RBBP7 expression significantly influences radiosensitivity in esophageal squamous cell carcinoma, varying with cell context.
  • Knockdown of RBBP7 in TE-1 cells enhanced radiosensitivity (SER=1.370), while in KYSE-150 cells, it reduced sensitivity (SER=0.775).
  • The study involved multiple assays including CCK-8 and Western blotting, assessing both cellular effects and signaling pathways.
  • Clinical analysis indicated RBBP7 positivity is linked to malignancy features like TNM stage and differentiation status.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d647839b4https://doi.org/10.2147/ott.s535750
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  4. 4Chromatin Remodeler RSF1 as an Oncogenic Driver and Therapeutic Target in Esophageal Squamous Cell Carcinoma2025
  5. 5Multidimensional analysis of the role of BRI3BP in the occurrence, development and prognosis of esophageal cancer2025