September 10, 2025Chemistry - A European JournalOpen Access

4‐Dimethylamino‐1,8‐Naphthalimide as a Fluorescence Signal Amplification for Site Selective and in Situ Probing of the Hydroxyl Radical

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Authors

YSYelisetty Venkata Suseela SMS.K. Mandal DJDenis Jacquemin

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This research demonstrates selective detection of hydroxyl radicals in biological systems using a fluorescence probe, highlighting its application in investigations of Cu binding to amyloid-beta.

Key Points

The study reports a ∼25-fold increase in quantum yield for the hydroxyl radical detection using 4‐dimethylamino‐1,8‐naphthalimide.
Hydroxyl radicals were selectively detected in situ with NMI coupled to amyloid-beta, showing the potential for complex biological applications.
Copper binding to amyloid-beta catalyzed hydroxyl radical production via a Fenton-type reaction, but these radicals were not detectable in complex media with scavengers.
This highlights NMI as a versatile tool for studying hydroxyl radicals in specific biological contexts like Cu-Aβ16 interactions.

Cite This Study

Suseela et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d6478394d https://doi.org/10.1002/chem.202502598

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Implication

This research demonstrates selective detection of hydroxyl radicals in biological systems using a fluorescence probe, highlighting its application in investigations of Cu binding to amyloid-beta.

4‐Dimethylamino‐1,8‐Naphthalimide as a Fluorescence Signal Amplification for Site Selective and in Situ Probing of the Hydroxyl Radical

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Key Points

Cite This Study

4‐Dimethylamino‐1,8‐Naphthalimide as a Fluorescence Signal Amplification for Site Selective and in Situ Probing of the Hydroxyl Radical

Discussion

Member takes

Implication

Key Points

Cite This Study

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