This study demonstrates how an iridium complex can detect mitochondrial peroxynitrite in liver cells, indicating its potential in assessing oxidative stress.
Key Points
The iridium(III) complex displays a 27-fold increase in luminescence when reacting with peroxynitrite, indicating its effectiveness.
The limit of detection for peroxynitrite using the complex is 0.65 μM, showcasing its sensitivity for imaging applications.
The complex can visualize exogenous peroxynitrite in 3D tumor spheroids, highlighting its capability in multicellular models.
Findings suggest a pathway involving NADPH oxidase 4 in the production of endogenous peroxynitrite, which may have clinical implications.