P-Doped Cu–N–C Single-Atom Catalysts Boost Cathodic Electrochemiluminescence of Luminol for MicroRNA-320d Detection

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This study demonstrates improved cathodic electrochemiluminescence via a novel catalyst, suggesting potential for cancer biomarker detection.

Enhanced electrochemiluminescence occurs through a P-doped copper catalyst, significantly optimizing luminol's reaction.
Detection limit of the developed biosensor stands at 0.158 fM for microRNA-320d, indicating high sensitivity.
A three-electron oxygen reduction pathway generates reactive oxygen species, amplifying electrochemiluminescent signals.
This research provides insights into developing advanced catalysts for fostering diagnostic techniques in clinical settings.

Liu et al. (2025) studied this question.

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This study demonstrates improved cathodic electrochemiluminescence via a novel catalyst, suggesting potential for cancer biomarker detection.