August 26, 2025PeerJOpen Access

Longitudinal changes in estimated glomerular filtration rates in chronic hepatitis B patients treated with Tenofovir Alafenamide vs Entecavir

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Discussion

Observational analysis shows comparable kidney safety of TAF and ETV in treatment-naïve individuals, suggesting TAF benefits men and older patients.

The TAF group showed a lower rate of eGFR decline compared to the ETV group, indicating better kidney safety.
In patients with a baseline eGFR above 90 mL/min/1.73 m2, CKD incidence was 13.9% for ETV and 9.8% for TAF, revealing no significant difference.
Cox regression analysis identified baseline eGFR and male gender as key factors associated with CKD development.
GAMM analysis indicated that eGFR initially declined in both groups but stabilized around week 40, highlighting the treatment dynamics.

Li et al. (2025) studied this question.

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Observational analysis shows comparable kidney safety of TAF and ETV in treatment-naïve individuals, suggesting TAF benefits men and older patients.