Comparative Efficacy and Renal Safety of Entecavir and Tenofovir Disoproxil Fumarate in the Treatment of Chronic Hepatitis B: A Retrospective Cohort Study From Vietnam

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Discussion

Retrospective cohort study compares efficacy and renal safety of TDF and ETV in Vietnamese CHB patients.

Both tenofovir disoproxil fumarate and entecavir provide effective antiviral therapy for chronic hepatitis B.
At Week 48, TDF showed 58% virologic suppression compared to 52% for entecavir, indicating comparable efficacy.
The retrospective cohort study analyzed 348 treatment-naïve Vietnamese patients over 48 weeks to evaluate outcomes.
Findings suggest tailored choices between TDF and ETV based on individual renal and liver health concerns.

Vo et al. (2025) studied this question.

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