September 10, 2025ObesityOpen Access

The Role of p53 in Adipocyte Differentiation and Lipid Metabolism in Obese Mice via Transcriptional Regulation of Lgals3

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Discussion

This investigation shows how p53 regulates Lgals3 in obesity, suggesting new therapeutic avenues for metabolic dysfunction.

p53 overexpression improved metabolic dysfunction in obesity by downregulating Lgals3 expression and inhibiting adipocyte differentiation.
Analysis revealed that high-fat diet mice had significant weight gain and elevated Lgals3 expression, impacting lipid metabolism.
The role of p53 in regulating Lgals3 was assessed using bioinformatics, mouse models, and in vitro 3T3-L1 cell experiments.
These findings highlight the interplay between p53 and Lgals3, indicating potential therapeutic targets for obesity-related metabolic disorders.

Li et al. (2025) studied this question.

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