Research shows p53 regulates insulin tolerance and intestinal microbiota in type 2 diabetes, indicating metabolic effects through specific signaling pathways.
Key Points
p53 deficiency worsens glucose and insulin tolerance in type 2 diabetic mice, leading to more severe symptoms.
Mice lacking p53 experience reduced intestinal microbiota diversity, affecting gut function and metabolic health.
Analysis of signaling pathways reveals p53 modulates insulin secretion via the PI3K/AKT pathway, influencing glucose metabolism.
The findings highlight p53's critical role in connecting gut health to liver function, impacting type 2 diabetes outcomes.