Dental pulp stem cells conditioned medium-functionalized microspheres for endodontic regeneration

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Discussion

This study demonstrates enhanced angiogenesis and differentiation in dental pulp stem cells using conditioned medium and microspheres.

NPM-loaded conditioned medium promotes odontogenic differentiation in dental pulp stem cells.
The study employed a semi-isotopic in vivo model to assess pulp-like tissue regeneration.
Nucleus pulposus microspheres exhibited good biocompatibility and supported regeneration.
Key bioactive cues in the conditioned medium facilitated pulp tissue regeneration in a 3D microenvironment.

Gao et al. (2025) studied this question.

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