September 10, 2025Open Access

Figure S9 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

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Discussion

Knockdown of PPARδ affects EMT-related gene expression in pancreatic cancer models, suggesting metabolic responses play a key role.

Alterations in gene expression linked to epithelial-mesenchymal transition were observed with PPARδ knockdown, revealing a role in metastasis.
Key findings indicate a connection between PPARδ activity and metabolic changes in pancreatic cancer derived xenografts.
The study utilizes patient-derived xenografts (PDXs) to assess metabolic responses influenced by microenvironmental factors.
Results highlight the importance of PPARδ in orchestrating a prometastatic metabolic response in pancreatic cancer.

Parejo-Alonso et al. (2025) studied this question.

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