Non-Skeletal Roles of Vitamin D in Skin, Gut, and Cardiovascular Disease: Focus on Epithelial Barrier Function and Immune Regulation in Chronic Disease

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Vitamin D enhances epithelial barrier function and regulates immune responses in chronic disease.
Research indicates that vitamin D can improve tight junction expression in inflammatory bowel disease and dermatitis.
Animal studies show vitamin D supplementation can reduce disease activity in dermatologic and gut disorders.
Individualized vitamin D approaches are necessary due to mixed outcomes in cardiovascular supplementation trials.

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This review highlights vitamin D's influence on epithelial barrier function and immune regulation in chronic diseases.

Grieco et al. (2025) studied this question.

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