July 25, 2025Open Access

Non-Skeletal Roles of Vitamin D: Epithelial Barrier Function and Immune Regulation in Chronic Disease

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Discussion

This review explores how vitamin d regulates epithelial barrier function and inflammation in chronic diseases, suggesting therapeutic implications.

Vitamin d plays a vital role in maintaining epithelial barrier integrity and regulating immune responses.
Evidence links vitamin d deficiency to chronic inflammatory conditions, such as atopic dermatitis and inflammatory bowel disease.
Vitamin d/VDR signaling enhances tight junction structure and modulates the gut and skin microbiome.
Supplementation may improve clinical outcomes in intestinal and dermatologic diseases, although results in cardiovascular contexts are mixed.

Grieco et al. (2025) studied this question.

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July 25, 2025Open Access

View Full Paper

Ask AI

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Authors

This review explores how vitamin d regulates epithelial barrier function and inflammation in chronic diseases, suggesting therapeutic implications.

Vitamin d plays a vital role in maintaining epithelial barrier integrity and regulating immune responses.
Evidence links vitamin d deficiency to chronic inflammatory conditions, such as atopic dermatitis and inflammatory bowel disease.
Vitamin d/VDR signaling enhances tight junction structure and modulates the gut and skin microbiome.
Supplementation may improve clinical outcomes in intestinal and dermatologic diseases, although results in cardiovascular contexts are mixed.

Grieco et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark