Macrophage Nogo-B drives liver fibrosis

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Nogo-B promotes liver fibrosis by enhancing macrophage activity and inflammation, worsening liver injury.
In mouse models, myeloid Nogo-B deficiency significantly reduced liver inflammation and fibrosis stages.
Nogo-B activates the NLRP3 inflammasome and necroptosis in macrophages via RIPK3 stabilization mechanisms.
These findings suggest a crucial role of Nogo-B in liver pathology, pointing to potential therapeutic targets.

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Findings reveal Nogo-B influences liver fibrosis through macrophage activation and inflammation.

Zhang et al. (2025) studied this question.

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