August 15, 2025Open Access

Rewired NAD⁺ metabolism promotes NF-κB-mediated oxidative stress and disrupts lipid homeostasis in liver fibrosis progression

View Full Paper

Ask AI

Bookmark

NAD+ metabolism disruption triggers oxidative stress in liver fibrosis, leading to potential cancer development.
Multi-omics analysis, including metabolomics, identified increased NAD+ precursors and reduced nicotinamide levels.
A chemically induced mouse model demonstrated how disrupted lipid homeostasis results from altered NAD+ pathways during fibrosis progression.
New insights could support the development of diagnostic biomarkers and therapeutic strategies for liver disease and cancer.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Multi-omics analysis reveals NAD+ metabolism disruption drives oxidative stress in liver fibrosis, implying new diagnostic targets for hepatocellular carcinoma.

Cite This Study

Ngan et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d6477224e https://doi.org/10.1101/2025.08.06.668888

View Full Paper

Ask AI

Bookmark

Implication

Multi-omics analysis reveals NAD+ metabolism disruption drives oxidative stress in liver fibrosis, implying new diagnostic targets for hepatocellular carcinoma.

Rewired NAD⁺ metabolism promotes NF-κB-mediated oxidative stress and disrupts lipid homeostasis in liver fibrosis progression

Key Points

Discussion

Implication

Cite This Study

Rewired NAD⁺ metabolism promotes NF-κB-mediated oxidative stress and disrupts lipid homeostasis in liver fibrosis progression

Key Points

Discussion

Implication

Cite This Study