July 29, 2025Current Issues in Molecular BiologyOpen Access

Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization

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SAL B effectively reduced inflammatory factors in liver fibrosis models induced by CCl4.
By inhibiting DNMT1, SAL B increased MIG1 expression, altering macrophage behavior.
The treatment blocked glycolysis-dependent M1 macrophage polarization through MIG1-mediated transcription changes.
SAL B presents a potential therapeutic option for managing liver fibrosis and its associated inflammation.

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Implication

Experiment observes reduced liver fibrosis in CCl4-induced models, suggesting that salvianolic acid B may inhibit glycolysis-mediated macrophage polarization.

Cite This Study

Song et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8ceca6 https://doi.org/10.3390/cimb47080598

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Implication

Experiment observes reduced liver fibrosis in CCl4-induced models, suggesting that salvianolic acid B may inhibit glycolysis-mediated macrophage polarization.

Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization

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Discussion

Implication

Cite This Study

Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization

Key Points

Discussion

Implication

Cite This Study

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