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September 10, 2025Open Access

Clinical Impact of Ultra-Fast Whole Genome Sequencing in Paediatric Haematology-Oncology Practice

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Authors

AVAditi VediJTJamie TrotmanJDJoão M.L. Dias

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Overview

Observational study shows ultra-fast whole genome sequencing reduces turnaround time in paediatric oncology, indicating improved diagnostics and care.

Key Points

  • Ultra-fast whole genome sequencing reduced turnaround time to a mean of 3 days, compared to 37 days for standard methods.
  • The ultra-fast approach recalled 95% of clinically actionable variants, uncovering additional actionable variants in 19 cases.
  • Improvements in patient care were seen in 51% of prospective cases with ultra-fast whole genome sequencing.
  • Over half of the clinicians agreed that retrospective cases could have benefited from real-time ultra-fast sequencing.

Cite This Study

Vedi et al. (2025) studied this question.

synapsesocial.com/papers/68c23a74b210217d647810b3https://doi.org/10.1101/2025.08.29.25334714
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Feasibility and utility of unmatched whole-genome sequencing (uWGS)  for pediatric acute leukemias: An analysis of leukemia precision-based therapy (LEAP) study samples2025
  2. 2Comprehensive and rapid detection of genomic alterations in pediatric leukemias using whole-genome sequencing with adaptive sampling2025 · 1 citations
  3. 3A SERVICE EVALUATION OF WHOLE GENOME SEQUENCING IN PRIMARY BRAIN TUMOURS AT A TERTIARY UK NEURO-ONCOLOGY CENTRE: CLOSING THE GAPS2025
  4. 4P05.27.A INTRODUCTION OF WHOLE GENOME SEQUENCING AS NHS STANDARD OF CARE FOR GLIOMA PATIENTS IN TWO NEUROSURGICAL CENTRES: WEST MIDLANDS2025
  5. 5Next-Generation Sequencing for Infectious Disease Diagnostics in Pediatric Patients with Malignancies or After Hematopoietic Cell Transplantation: A Systematic Review2025