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December 8, 2025BloodOpen Access

Feasibility and utility of unmatched whole-genome sequencing (uWGS)  for pediatric acute leukemias: An analysis of leukemia precision-based therapy (LEAP) study samples

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Authors

JGJesús Gutiérrez‐AbrilJOJuan Arango OssaSTSarah K. Tasian

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Overview

Analysis reveals unmatched whole-genome sequencing improves diagnostics of pediatric acute leukemias, identifying oncogenic events and genomic rearrangements.

Key Points

  • uWGS identified oncogenic events in 91% of pediatric acute leukemias, enhancing diagnostics.
  • Concordance with standard techniques was high, showing 95% agreement with karyotyping and 100% with FISH.
  • Assessment of 68 samples highlighted the value of genomic rearrangements in pediatric populations.
  • Findings support expanded use of uWGS for improved leukemia management and precision-based therapy.

Cite This Study

Gutiérrez‐Abril et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d978https://doi.org/10.1182/blood-2025-2561
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comprehensive and rapid detection of genomic alterations in pediatric leukemias using whole-genome sequencing with adaptive sampling2025 · 1 citations
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