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September 5, 2025Open Access

The Role of Selected Inflammatory Cytokines and Chemokines, Including IL-6, IL-13 and TNF-α, in the Pathogenesis of COVID-19

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Authors

AGAlicja GospodarczykCWCelina WojciechowskaPDPaweł Dolibog

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Overview

Observational analysis found elevated IL-6 and TNF-α in COVID-19 patients, suggesting immune dysfunction's impact on severity.

Key Points

  • The study highlights significant elevations of IL-6, IL-13, and TNF-α in COVID-19 patients compared to non-COVID individuals, indicating a link to severe disease.
  • Results showed statistically significant higher values of cytokines in the COVID group, emphasizing inflammatory responses' role in disease severity.
  • Observational analysis involved 57 patients, assessing cytokine levels to explore the connection with COVID-19 severity and outcomes.
  • Understanding cytokine storm mechanisms may aid in identifying at-risk patients and inform targeted treatments or vaccines.

Cite This Study

Gospodarczyk et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477ef24https://doi.org/10.20944/preprints202509.0071.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role Of Cytokines and Other Prophetic Variables in The Development and Progression of Disease in Patients Suffering from Covid-192023
  2. 2Chemokines as potential biomarkers for predicting the course of COVID-19 – a review of the literature2025
  3. 3Cytokines dynamics and biological sex differences in SARS-CoV-2 infected people in Cameroon2025
  4. 4Association of pro-inflammatory and anti-inflammatory cytokine polymorphisms with COVID-19 severity in unvaccinated patients2025
  5. 5Identification of blood immunological biomarkers of SARS-CoV-2 infection during pandemic in Poland2025