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September 25, 2025Frontiers in ImmunologyOpen Access

Chemokines as potential biomarkers for predicting the course of COVID-19 – a review of the literature

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Authors

BWBlanka Wolszczak-BiedrzyckaBCBeata CieślikiewiczFSFilip Studniarz

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Overview

Literature review explores chemokines as potential biomarkers for COVID-19, indicating higher levels in severe cases.

Key Points

  • Chemokines are identified as significant biomarkers to assess the severity of COVID-19 infections, enhancing clinical risk analysis.
  • Levels of chemokines like CCL2, CCL3, CCL5, CXCL8, and CXCL10 are notably higher in COVID-19 patients compared to controls.
  • Understanding the role of chemokines can improve prognostic evaluations for patients at risk of complications and severe outcomes.
  • Cytokine storm in COVID-19 is triggered by SARS-CoV-2 interactions with ACE2, leading to a dangerous immune response.

Cite This Study

Wolszczak-Biedrzycka et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd6edc445aa9033b0997https://doi.org/10.3389/fimmu.2025.1662643
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Selected Inflammatory Cytokines and Chemokines, Including IL-6, IL-13 and TNF-α, in the Pathogenesis of COVID-192025
  2. 2Role Of Cytokines and Other Prophetic Variables in The Development and Progression of Disease in Patients Suffering from Covid-192023
  3. 3Identification of blood immunological biomarkers of SARS-CoV-2 infection during pandemic in Poland2025
  4. 4Anti-SARS-CoV-2 Antibody Subclass Response and Cytokine Storm in Severe COVID-19 Patients Under Intensive Care Unit2025
  5. 5Biochemical and Immune Indicators of COVID-19 Severity2025