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September 5, 2025Korean Journal of Legal MedicineOpen Access

Catecholaminergic Polymorphic Ventricular Tachycardia Diagnosed Using Postmortem Next-Generation Sequencing: An Autopsy Case Report

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Authors

JLJunghye Lee

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Overview

Case report identifies CPVT through genetic testing in a 15-year-old, indicating need for improved practices in forensic investigations.

Key Points

  • Genetic testing identified the cause of death as CPVT, potentially preventing future cases.
  • The pathogenic RYR2 variant was found through postmortem sequencing in an unremarkable autopsy.
  • Integration of genetic testing into autopsy practices may enhance diagnostic certainty and family counseling.
  • Postmortem genetic testing is not yet standard in South Korean forensic investigations, highlighting a gap in practice.

Cite This Study

Junghye Lee (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477eb7ehttps://doi.org/10.7580/kjlm.2025.49.3.88
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trauma triggered catecholaminergic polymorphic ventricular tachycardia manifesting as cardiac arrest in a child: a case report2026
  2. 2Progressively complex exercise-induced ventricular arrhythmias unveiling catecholaminergic polymorphic ventricular tachycardia associated with a novel RYR2 variant in a competitive athlete: a case report2026 · 1 citations
  3. 3Unusual catecholaminergic polymorphic ventricular tachycardia and bradycardia caused by a novel triadin variant in 2 siblings from a Malian family2025
  4. 4Polymorphic ventricular tachycardia with mutation in KCNJ2: case report2026
  5. 5Concealed Cardiomyopathy in Autopsy-Inconclusive Cases of Sudden Cardiac Death and Implications for Families2022 · 59 citations