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May 22, 2026European Heart Journal - Case ReportsOpen Access

Serial exercise-based testing unmasked the arrhythmic substrate, leading to the diagnosis of CPVT confirmed by the identification of a novel pathogenic RYR2 variant through familial co-segregation.

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Population

A young asymptomatic female competitive football player with a structurally normal heart who developed…

Design

Case_report

Follow-up

several years

Authors

MVMarco VecchiatoAZAlessandro ZorziKPKalliopi Pilichou

Discussion

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Overview

May prompt genetic testing in athletes with progressive exercise-induced arrhythmias; extends CPVT variant spectrum but leaves management implications open.

Structured PICO

P
Population
A young asymptomatic female competitive football player with a structurally normal heart who developed progressively complex exercise-induced ventricular arrhythmias.
I
Intervention
Serial exercise-based testing and comprehensive family genetic evaluation.
O
Outcome
Diagnosis of catecholaminergic polymorphic ventricular tachycardia (CPVT) and identification of a novel pathogenic RYR2 variant.

Serial exercise testing and comprehensive family genetic evaluation are crucial for unmasking concealed CPVT in athletes with initially unremarkable resting investigations.

Cite This Study

Vecchiato et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff452d674f7c03778d8a5https://doi.org/10.1093/ehjcr/ytag377
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RYR2 Variants in Catecholaminergic Polymorphic Ventricular Tachycardia Patients: Insights From Protein Structure and Clinical Data2025
  2. 2Catecholaminergic Polymorphic Ventricular Tachycardia Diagnosed Using Postmortem Next-Generation Sequencing: An Autopsy Case Report2025
  3. 3Trauma triggered catecholaminergic polymorphic ventricular tachycardia manifesting as cardiac arrest in a child: a case report2026
  4. 4Paddling Through Palpitations: When Genes, Myocardial Inflammation and Exercise Collide – A Case Report of Arrhythmogenic Cardiomyopathy in a Young Competitive Rower2025
  5. 5Ventricular arrhythmias in athletes: morphologic features and risk stratification of pathological myocardial substrate2026