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September 10, 2025MedicineOpen Access

Unusual catecholaminergic polymorphic ventricular tachycardia and bradycardia caused by a novel triadin variant in 2 siblings from a Malian family

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Authors

MDM. DiakitéOSOumar SamassékouKSKoudoussou Olaréwadjou Sanni

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Overview

Case report reveals a novel triadin variant causing CPVT and bradycardia in siblings, highlighting genetic implications.

Key Points

  • Both patients with recurrent syncope and bradycardia, indicating a unique presentation of CPVT.
  • A novel homozygous TRDN variant identified through whole-exome sequencing was classified as pathogenic.
  • Treatment with nadolol effectively resolved syncope and reduced arrhythmic episodes during follow-up.
  • This is the first genetically confirmed TRDN variant case documented in sub-Saharan Africa, expanding the known spectrum.

Cite This Study

Diakité et al. (2025) studied this question.

synapsesocial.com/papers/68c23f63b210217d647961f7https://doi.org/10.1097/md.0000000000043596
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