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August 5, 2025International Healthcare Review (online)

The Role of PTEN Tumor Suppressor Genes in Endometrial Cancer

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Authors

CPCristina PazConsejo Nacional de Investigaciones Científicas y TécnicasLVLaíza Virnia Cortes VianaUniversidade Municipal de São Caetano do SulMBManuel Martínez BuenoUniversidad de Granada

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Implication

Systematic review highlights PTEN mutations' link to endometrial cancer, suggesting targeted therapies may improve outcomes.

Key Points

  • PTEN mutations are found in about 50% of endometrial cancer cases, particularly in high-grade tumors.
  • These mutations impair PTEN function, allowing damaged cells to evade apoptosis and continue growing.
  • Tumors with PTEN mutations show resistance to standard treatments like chemotherapy and radiotherapy.
  • Targeting the PI3K/AKT pathway may offer new therapeutic avenues for managing endometrial cancer with PTEN mutations.

Cite This Study

Paz et al. (2025) studied this question.

synapsesocial.com/papers/689522009f4f1c896c428ff0https://doi.org/10.56226/114
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