September 25, 2025Frontiers in MicrobiologyOpen Access

Polysaccharide from Trichosanthes kirilowii Maxim ameliorates diphenoxylate-induced functional constipation in mice

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Discussion

Animal study shows polysaccharide alleviated gastrointestinal issues in constipated mice, highlighting its therapeutic potential.

TKP significantly improved fecal excretion and gastrointestinal transit in mice with functional constipation.
Treatment with TKP altered neurotransmitter levels, increasing excitatory types while decreasing inhibitory ones.
Colonic inflammation markers decreased under TKP, supporting its role in managing oxidative stress.
TKP enhanced gut microbiota diversity and increased short-chain fatty acid production in constipated mice.

Jiang et al. (2025) studied this question.

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