Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Journal of CancerOpen Access

Prognostic Implications and Immune Landscape Analysis of Necroptosis-associated Gene Signatures in Acute Myeloid Leukemia

View Full Paper
Ask AI
Bookmark
Share

Authors

ZZZongsi ZhuBLBing LiPLPing Li

Discussion

Loading...

Member takes

Overview

Analysis reveals immune cell infiltration and poor prognosis linked to necroptosis gene signatures in AML.

Key Points

  • Developed a prognostic model indicating suppressed necroptosis correlates with adverse AML outcomes.
  • Identified two necroptosis-related gene clusters, with Cluster B showing poorer prognosis and higher immune infiltration.
  • Assessment revealed strong links between gene expression profiles and immune microenvironment modifications.
  • qRT-PCR confirmed significant differences in key necroptosis-related genes between AML cells and normal PBMCs.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d64795146https://doi.org/10.7150/jca.113136
View Full Paper
Ask AI
Bookmark
Share