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September 10, 2025

Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration.

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Authors

TWTao WangFDFei DingKSKai Sun

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Overview

Research identifies a five-gene necroptosis-related prognostic signature in bladder cancer, suggesting implications for tumor immune infiltration.

Key Points

  • The study identified five prognostic necroptosis-related genes that influence survival outcomes in bladder cancer patients.
  • Using Cox proportional hazards modeling and LASSO regression, a predictive model was created, showing moderate accuracy in prognosis.
  • Bioinformatics analyses revealed correlations between necroptosis gene expression and various immune parameters in bladder cancer.
  • Immunohistochemical validation confirmed dysregulated expression of the identified necroptosis-related genes in bladder cancer tissues.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d6478536ehttps://doi.org/10.3389/fgene.2025.1527907
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