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September 23, 2025Current Cancer Drug Targets

Multi-omics Approaches to CCAAT/Enhancer-Binding Protein Beta in Oral Squamous Cell Carcinoma: Crosstalk Between Tumor Cells and Tumor-Associated Macrophages Driving Disease Progression

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Authors

MLMin LiJLJilun LiuWZWenjuan Zhang

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Overview

This analysis reveals the role of CEBPB in OSCC progression and its crosstalk with tumor-associated macrophages, suggesting therapeutic targets.

Key Points

  • CEBPB is upregulated in oral squamous cell carcinoma and linked to poor patient prognosis.
  • Integrating RNA-seq and ChIP-seq data identified 131 genes regulated by CEBPB in metastatic OSCC.
  • CEBPB enhances chemotaxis of OSCC cells toward macrophages, promoting an immunosuppressive tumor microenvironment.
  • GAS6 acts as an important mediator of CEBPB in facilitating macrophage interactions and polarization.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d4409f713b0b5dfea7facehttps://doi.org/10.2174/0115680096387374250823190214
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