September 5, 2025Open Access

Uncovering the PML::RARA Fusion in Cytogenetically Cryptic and FISH-Negative Acute Promyelocytic Leukemia - A Case Report and Comprehensive Literature Review

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Case report reveals PML::RARA fusion detection challenges in acute promyelocytic leukemia, highlighting the need for molecular testing.

Detection of a PML::RARA fusion in a FISH-negative acute promyelocytic leukemia case led to a delayed diagnosis.
The patient experienced severe complications despite early intervention with all-trans retinoic acid.
This case underscores the importance of integrating molecular testing in routine diagnostics for acute promyelocytic leukemia.
The literature review confirms that RT-PCR effectively detects cryptic fusions in cytogenetically negative acute promyelocytic leukemia cases.

Delikkaya et al. (2025) studied this question.

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