September 10, 2025Frontiers in OncologyOpen Access

A case report of TBL1XR1-RARB positive pediatric acute promyelocytic leukemia and literature review

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Discussion

Case report describes pediatric acute promyelocytic leukemia driven by TBL1XR1-RARB, highlighting ATRA/ATO resistance and relapse.

Patient presented with neutrophilic leukocytosis and fever, indicating atypical acute promyelocytic leukemia behaviors.
Literature review showed a predominant pediatric occurrence with a median age of 2.7 years and 55% ATRA/ATO resistance.
Relapse occurred during maintenance therapy, emphasizing significant diagnostic and therapeutic challenges in this rare leukemia variant.
This study highlights the molecular heterogeneity of TBL1XR1-RARB-positive APL and the need for tailored management strategies.

Du et al. (2025) studied this question.

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